Bioactive Proteins Research

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Literature

Learn about the history of bioactive proteins, their effect on intestinal health, the integrity of the intestinal barrier, the intestinal microbiota and intestinal inflammation.

Scientific Research

A printable biblography of relevant scientific studies of bioactive proteins. 

 

EQUINE ULCER PREVENTION STUDY 

Accepted in the Journal of Equine Science on the effect of serum based bioactive proteins for the prevention of squamous gastric ulcers in horses. 

Study highlights:

 

EQUINE MARE/FOAL STUDY 

Published in the Journal of Equine Science on the effects of bioactive proteins for peripartum mares and their neonatal foals.

 

EQUINE GAIT ANALYSIS STUDY

Administration of Bioactive Proteins to Mature Horses Improves Gait Kinematics

 

BIOACTIVE PROTEIN RESEARCH BIBLIOGRAPHY


MODE OF ACTION | RESPIRATORY | DIGESTIVE | IMMUNITY | INFLAMMATION | STRESS | REPRODUCTION | WEANING

Mode of Action

Campbell, J.M., J. Polo, L.E. Russell and J.D. Crenshaw. 2010. Review of spray-dried plasma’s impact on intestinal barrier function.  Livest. Sci. 133:239-241.

Crenshaw, J.D., J. Polo, and J. Campbell. 2013. SDP effective in swine diets for various stages. Feedstuffs, Vol 85 (25):12-13.

Maijó, M. L. Miró, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, M. Moretó, and A. Pérez-Bosque. 2011. Dietary plasma proteins attenuate the innate immunity response in a mouse model of acute lung injury. Brit. J Nutr. 107:867-875.

Maijó, M. L. Miró, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, M. Moretó, and A. Pérez-Bosque. 2012. Dietary plasma proteins modulate the adaptive immune response in mice with acute lung inflammation. J Nutr. 142:264-270.

Moretó, M., and A. Pérez-Bosque. 2009.  Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa.  J. Anim. Sci. 87(E. Suppl.):E92-E100.

Moretó M., L. Miró, M. Maijó, J. Polo, E. Weaver, J. Crenshaw, L. Russell, J. Campbell, A. Pérez-Bosque. 2010. Dietary Supplementation with Porcine Plasma Proteins Reduce Lymphocyte Recruitment and Cytokine and Chemokine Expression in a Mouse Model of Spontaneous Colitis. Digestive Disease Week (DDW).

Moretó M., L. Miró, M. Maijó, J. Polo, L. Russell, J. Campbell, E. Weaver, J. Crenshaw, and A. Pérez-Bosque. 2013. Dietary plasma protein supplementation ameliorates lung and intestinal inflammation induced by lipopolysaccharide and staphylococcal enterotoxin B administration in mice. IUNS 20th Intl. Congress of Nutr. Granada, Spain, September 15-20, 2013.                                                                                

Pérez-Bosque, A., C. Pelegrí, M. Vicario, M. Castell, L. Russell, J. M. Campbell, J. D. Quigley, III, J. Polo, C. Amat and M. Moretó. 2004. Dietary plasma protein affects the immune response of weaned rats challenged with S. aureus superantigen B.   J. Nutr. 134:2667-2672.

Pérez-Bosque, A., A. Concepció, J. Polo, J. M. Campbell, J. Crenshaw, L. Russell and M. Moretó. 2006. Spray-dried animal plasma prevents the effects of Staphylococcus aureus Enterotoxin B on intestinal barrier function in weaned rats. J. Nutr. 136:2838-2843.

Pérez-Bosque, A., L. Miró, J. Polo, L. Russell, J. Campbell, E. Weaver, J. Crenshaw and M. Moretó. 2010. Dietary plasma protein supplements prevent the release of mucosal proinflammatory mediators in intestinal inflammation in rats. J. Nutr. 140:23-30.

 
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Respiratory System

Campbell, J., J. Crenshaw, and J. Polo. 2011. Impact of feeding spray-dried plasma to pigs challenged with swine influenza virus. Proceedings of the International Symposium on Emerging and Re-emerging Pig Diseases. Barcelona, Spain. June 12-15, 2011. Poster 185, p 269.

Campbell, J.M., J.D. Quigley, III, L.E. Russell, and L.D. Koehnk. 2004. Efficacy of spray-dried bovine serum on health and performance of turkeys challenged with Pasteurella multocida.  J. Appl. Poult. Res. 13:388-393.

Diaz, I., C. Lorca, I. Gallindo, J. Campbell, I. Barranco, L. Kuzemtseva, I.M. Rodriguez-Gomez, J. Crenshaw, L. Russell, J. Polo and J. Pujols. 2010. Potential positive effect of commercial spray-dried porcine plasma on pigs challenged with PRRS virus. Proc. 21st International Pig Veterinary Society, Vancouver, Canada, p 560.

Maijó, M. L. Miró, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, M. Moretó, and A. Pérez-Bosque. 2011. Dietary plasma proteins attenuate the innate immunity response in a mouse model of acute lung injury. Brit. J Nutr. 107:867-875.

Maijó, M. L. Miró, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, M. Moretó, and A. Pérez-Bosque. 2012. Dietary plasma proteins modulate the adaptive immune response in mice with acute lung inflammation. J Nutr. 142:264-270.

 
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Digestive System

Campbell, J.M., J. Polo, L.E. Russell and J.D. Crenshaw. 2010. Review of spray-dried plasma’s impact on intestinal barrier function.  Livest. Sci. 133:239-241.

Coffey, R. D., and G. L. Cromwell. 1995. The impact of the environment and antimicrobial agents on the growth response of early-weaned pigs to spray-dried porcine plasma. J. Anim. Sci. 75:2532-2539.

Corl, B.A., R.J. Harrell, H.K. Moon, O. Phillips, E.M. Weaver, J.M. Campbell, J.D. Arthington, and J. Odle. 2007. Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus. J. Nutr. Biochem. 18:778-784.

Crenshaw, J.D., J.M. Campbell and D. Quam. 2003. Evidence of gastric ulcer tissue repair in swine offered Solutein via the water. Amer. Ass. of Swine Vet., p 105-109.

Garriga, C., A. Pérez-Bosque, C. Amat, J. M. Campbell, L. Russell, J. Polo, J. M. Planas and M. Moretó. 2005. Spray-dried porcine plasma reduces the effects of Staphylococcal enterotoxin B on glucose transport in rat intestine. J. Nutr. 135:1653-1658.

Nofrarías, M., E. G. Manzanilla, J. Pujols, X. Gilbert, N. Majó, J. Segalés, and J. Gasa. 2006. Effects of spray-dried porcine plasma and plant extracts on intestinal morphology and on leukocyte cell subsets of weaned pigs. J. Anim. Sci. 84:2735-2742.

Pérez-Bosque, A., A. Concepció, J. Polo, J. M. Campbell, J. Crenshaw, L. Russell and M. Moretó. 2006. Spray-dried animal plasma prevents the effects of Staphylococcus aureus Enterotoxin B on intestinal barrier function in weaned rats. J. Nutr. 136:2838-2843.

Quigley, J.D. III, J.M. Campbell, J. Polo, and L.E. Russell. 2004. Effects of spray-dried animal plasma on intake and apparent digestibility in dogs. J. Anim. Sci. 82:1685–1692.

Rodriguez et al. 2007. Porcine immunoglobulins survival in the intestinal tract of adult dogs and cats fed dry food kibbles containing spray-dried porcine plasma (SDPP) or porcine immunoglobulin concentrate (PIC). Anim. Feed Sci. Tech. 139:201-211.

Torrallardona, D., M. R. Conde, I. Badiola, J. Polo, and J. Brufau. 2003. Effect of fishmeal replacement with spray-dried animal plasma and colistin on intestinal structure, intestinal microbiology, and performance of weanling pigs challenged with Escherichia coli K99. J. Anim. Sci. 81:1220–1226.

 
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Immunity

Bosi, P., I.K. Han, H.J. Jung, K.N. Heo, S. Perini, A.M. Castellazzi, L. Casini, D. Creston, and C. Gremokilini.  2001. Effect of different spray dried plasmas on growth, ileal digestibility, nutrient deposition, immunity and health of early-weaned pigs challenged with E. coli K88. Asian-Aust. J. Anim. Sci. 14:1138-1143.

Moeser, A., J. Campbell, J. Crenshaw and J. Polo. 2013. Long term effects of spray-dried plasma in nursery diets on intestinal immune response to subsequent stress. J. Anim. Sci. 91(Suppl. 2):119.

Moretó M, L. Miró, M. Maijó, J. Polo, E. Weaver, J. Crenshaw, L. Russell, J. Campbell, A. Pérez-Bosque. 2009. Dietary Porcine Plasma Protein Supplements Attenuate the Changes in Colitis Markers in the mdr1a-/-Mouse Model of Colitis. Digestive Disease Week (DDW). Poster W2005. Chicago. USA.

Moretó, M., and A. Pérez-Bosque. 2009.  Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa.  J. Anim. Sci. 87(E. Suppl.):E92-E100.

Nofrarías, M., E. G. Manzanilla, J. Pujols, X. Gilbert, N. Majó, J. Segalés, and J. Gasa. 2006. Effects of spray-dried porcine plasma and plant extracts on intestinal morphology and on leukocyte cell subsets of weaned pigs. J. Anim. Sci. 84:2735-2742.

Pérez-Bosque, A., C. Pelegrí, M. Vicario, M. Castell, L. Russell, J. M. Campbell, J. D. Quigley, III, J. Polo, C. Amat and M. Moretó. 2004. Dietary plasma protein affects the immune response of weaned rats challenged with S. aureus superantigen B.   J. Nutr. 134:2667-2672.

Pérez-Bosque, A., L. Miró, J. Polo, L. Russell, J. Campbell, E. Weaver, J. Crenshaw and M. Moretó. 2008. Dietary plasma proteins modulate the immune response of diffuse GALT in rats challenged with Staphylococcus aureus Enterotoxin B.   J. Nutr. 138:533-537.

Pérez-Bosque, A., L. Miró, J. Polo, L. Russell, J. Campbell, E. Weaver, J. Crenshaw and M. Moretó. 2010. Dietary plasma protein supplements prevent the release of mucosal proinflammatory mediators in intestinal inflammation in rats. J. Nutr. 140:23-30.

Song, M., Y. Liu, J.J. Lee, J.A. Soares, T.M. Che, J.M. Campbell, J. Polo, J.C. O’Connor and J.E. Pettigrew. 2011. Effects of spray-dried plasma on immune responses of pregnant mice to lipopolysaccharide as a model for inflammation in sows. J. Anim. Sci. Vol. 89, (E-Suppl. 1):580.

 
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Inflammation

Bosi, P., L. Casini, A. Finamore, C. Cremokolini, G. Merialdi, P. Trevisi, F. Nobili, and E. Mengheri. 2004. Spray-dried plasma improves growth performance and reduces inflammatory status of weanling pigs challenged with enterotoxigenic Escherichia coli K88. J. Anim. Sci. 82:1764-1772.

Harrell, R.J., H.K. Moon, E.M. Weaver, J.M. Campbell, J.A. Arthington, and J. Odle. 2000. Effects of animal plasma proteins on intestinal recovery of neonatal pigs infected with rotavirus. FASEB J. 14:A728.

Jiang, R., X. Chang, B. Stoll, M. Z. Fan, J. Arthington, E. Weaver, J. Campbell, and D. G. Burrin. 2000.  Dietary plasma protein reduces small intestinal growth and lamina propria cell density in early weaned pigs. J. Nutr. 130:21-26.

Maijó, M. L. Miró, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, M. Moretó, and A. Pérez-Bosque. 2012. Dietary plasma proteins modulate the adaptive immune response in mice with acute lung inflammation. J Nutr. 142:264-270.

Peace, R.M., J. Campbell, J. Polo, J. Crenshaw, L. Russell, and A. Moeser. 2011. Spray-dried porcine plasma influences intestinal barrier function, inflammation and diarrhea in weaned pigs. J. Nutr. 141:1312-1317.

Pérez-Bosque, A., L. Miró, J. Polo, L. Russell, J. Campbell, E. Weaver, J. Crenshaw and M. Moretó. 2010. Oral plasma proteins attenuate gut inflammatory effects induced by S. aureus enterotoxin B challenge in rats. Livestock Science 133: 242-245.

Song, M., Y. Liu, J. Lee, T.M. Che, J.A. Soares-Almeida, J.M. Campbell, J. Polo, J.D. Crenshaw, J.L Chun, S. Seo, and J.E. Pettigrew. 2012. Dietary spray-dried plasma attenuates inflammation caused by transport stress and increases pregnancy rate of mated female mice. FASEB J 26:1027.3

 
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Stress

Campbell, J.M., L.E. Russell, J.D. Crenshaw, and H.J. Koehnk. 2006. Effect of spray-dried plasma form and duration of feeding on broiler performance during natural necrotic enteritis exposure. J. Appl. Poult. Res. 15:584:591.

Crenshaw, J.D., J. Polo, and J. Campbell. 2013. SDP effective in swine diets for various stages. Feedstuffs, Vol 85 (25):12-13.

DePersio, S.A., K.W. Koelkebeck, J.M. Campbell, K. Lima, P.C. Harrison, C.W. Utterback, P.L. Utterback, A. Green, and R. Gates. 2011. Evaluation of spray-dried bovine plasma on production performance of laying hens exposed to acute heat stress temperature. Poult. Sci. 90 (E-Suppl. 1):117.

Hunt, E., Q. Fu, M.U. Armstrong, D.K. Rennix, D.W. Webster, J.A. Galanko, W. Chen, E.M. Weaver, R.A. Argenzio, and J.M. Rhoads.  2002.  Oral bovine serum concentrate improves crytosporidial enteritis in calves.  Pediatr. Res.  51:370-376.

Moeser, A., J. Campbell, J. Crenshaw and J. Polo. 2013. Long term effects of spray-dried plasma in nursery diets on intestinal immune response to subsequent stress. J. Anim. Sci. 91(Suppl. 2):119.

Pineda, A., J.K. Drackley, and J.M. Campbell.  2010.  Evaluation of serum-based arrival formula and serum protein (Gammulin) on growth, morbidity, and mortality of stressed dairy calves.  J. Dairy Sci. 93(E-Suppl. 1):541.

Quigley, J.D., III and M.D. Drew. 2000. Effects of oral antibiotics or IgG on survival, health and growth in dairy calves challenged with Escherichia coli. Food and Agricultural Immunology 12:311-318.

Torrallardona, D., M. R. Conde, I. Badiola, J. Polo, and J. Brufau. 2003. Effect of fishmeal replacement with spray-dried animal plasma and colistin on intestinal structure, intestinal microbiology, and performance of weanling pigs challenged with Escherichia coli K99. J. Anim. Sci. 81:1220–1226.

Van Dijk, A. J., P.M.M. Enthoven, S.G.C. Van den Hoven, M.M.M.H. Van Laarhoven, T. A. Niewold, M.J.A. Nabuurs, A.C. Beynen. 2002. The effect of dietary spray-dried porcine plasma on clinical response in weaned piglets challenged with a pathogenic Escherichia coli. Vet. Microbiol. 84:207-218.

Weaver, A. C., J. Campbell, J. D. Crenshaw, J. Polo, and S.W. Kim. 2013. Efficacy of plasma protein to mitigate the negative effects on performance of pigs fed mycotoxin contaminated corn. J. Anim. Sci. 91(Suppl. 2):12-13.

 
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Reproductive System

Campbell, J., T. Donavan, R.D. Boyd, L. Russell, and J. Crenshaw. 2006. Use of statistical process control analysis to evaluate the effects of spray-dried plasma in gestation and lactation feed on sow productivity in a PRRS-unstable farm. Amer. Assoc. Swine Vet., p 139-142.

Crenshaw, J. D, R. D. Boyd, J. M. Campbell, L. E. Russell, R. L. Moser, and M. E. Wilson. 2007. Lactation feed disappearance and wean to estrus interval for sows fed spray-dried plasma. J. Anim. Sci. 85:3442-3453.

Crenshaw, J. D., J. M. Campbell, L. E. Russell, and J. P. Sonderman. 2008. Effect of spray-dried plasma in diets fed to lactating sows on litter weight at weaning and subsequent farrowing rate. Proc. Allen D. Leman Swine Conf., Univ. MN, St. Paul, MN, p 47.

Crenshaw, J.D., J. M. Campbell, L. E. Russell, L. L. Greiner, J. Soto, and J. F. Connor. 2010. Effect of spray-dried plasma fed during gestation on pig performance at weaning. Proc. Allen D. Leman Swine Conf. Recent Research Supplement, Univ. MN, St. Paul, MN, p 193.

Song, M., Y. Liu, J.J. Lee, J.A. Soares, T.M. Che, J.M. Campbell, J. Polo, J.C. O’Connor and J.E. Pettigrew. 2011. Effects of spray-dried plasma on immune responses of pregnant mice to lipopolysaccharide as a model for inflammation in sows. J. Anim. Sci. Vol. 89, (E-Suppl. 1):580.

Song, M., Y. Liu, J. Lee, T.M. Che, J.A. Soares-Almeida, J.M. Campbell, J. Polo, J.D. Crenshaw, J.L Chun, S. Seo, and J.E. Pettigrew. 2012. Dietary spray-dried plasma attenuates inflammation caused by transport stress and increases pregnancy rate of mated female mice. FASEB J 26:1027.3

Song, M., J. Lee, Y. Liu, J.A. Soares, T.M. Che, J.M. Campbell, J. Polo, S.W. Seo, and J.E. Pettigrew. 2012. Effect of graded levels of dietary spray-dried plasma on pregnancy rate of mated female mice under transport stress as a model for stressed sows. J. Anim. Sci. Vol. 90, (E-Suppl. 2):112.

Song, M., J.A. Soares, Y. Liu, J.J. Lee, T.M. Che, J.M. Campbell, J. Polo, S.W. Seo, and J.E. Pettigrew. 2012. Effect of graded levels of dietary spray-dried plasma on growth and fetal characteristics of pregnant mice as a model for sows. J. Anim. Sci. Vol. 90 (E-Suppl. 2):112.

Van Iersel, H., C. Rodriguez, J. Polo, J.M. Campbell, J.D. Crenshaw and L. Rotelli. 2011. Effect of spray-dried plasma in lactation feed on pig survival and litter weight at a commercial farm in Italy. Proc. Allen D. Leman Swine Conf., Recent Research Reports, College of Veterinary Medicine, Univ. MN, St. Paul, MN, Vol. 38, p 281.

Vitagliano, L.A., L.F.S. Rangel, and J.D. Crenshaw. 2009. Effect of a supplement containing spray-dried plasma fed from mating to day 35 of gestation on farrowing rate of multiparous sows. Proc. Allen D. Leman Swine Conf. Recent Research Supplement, Univ. MN, St. Paul, MN, p 193.

Arthington, J.D., M.B. Cattell, J.D. Quigley, G.C. McCoy, and W.L. Hurley. 2000. Passive immunoglobulin transfer in newborn calves fed colostrums or spray-dried serum protein alone or as a supplement to colostrums of varying quality . J. Dairy Sci. 83:2834-2838.

Bikker, P., G. Kranendonk, R. Gerritsen, L. Russell, J. Campbell, J. Crenshaw, C. Rodríguez, J. Ródenas, and J. Polo. 2010. Absorption of orally supplied immunoglobulins in neonatal piglets. Livest. Sci. 134:139-142.

Campbell, J.M., L.E. Russell, J.D. Crenshaw, E.M. Weaver, S. Godden, J.D. Quigley, J. Cloverdale and H. Tyler. 2007. Impact of irradiation and immunoglobulin G concentration on absorption of protein and Immunoglobulin G in calves fed colostrum replacer. J Dairy Sci. 90:5726-5731.

Campbell, J., S. Jacobi, Y. Liu, K. Hard-Robertson, J. Drayton, I. Medina, J. Polo, J. Crenshaw, and J. Odle.  2012.  Evaluation of immunolglobulin G abosorption from colostrums supplements gavages to newborn piglets.  J. Anim. Sci. 90:299-301.

Elizondo-Salazar, J.A., R.F. Leuer, J.M. Campbell, and A.J. Heinrichs.  2008.  Absorption of total immunoglobulin G in dairy calves fed a colostrum replacement.  J. Dairy Sci. 91(E-Suppl. 1):192.

Hammer, C.J., J.D. Quigley, L. Ribeiro, and H.D. Tyler.  2004.  Characterization of a colostrum replacer and a colostrum supplement containing IgG concentrate and growth factors.  J. Dairy Sci. 87:106-111.

Polo, J., J. M. Campbell, J. Crenshaw, C. Rodríguez, N. Pujol, N. Navarro, and J. Pujols. 2012. Half-life of porcine antibodies absorbed from a colostrum supplement containing porcine immuno-globulins. J. Anim. Sci. 90:308-310.

Quigley, J. D., III, D. L. Fike, M. N. Egerton, J. J. Drewry, and J. D. Arthington. 1998. Effects of a colostrum replacement product derived from serum on immunoglobulin G absorption by calves. J. Dairy Sci. 81:1936-1939.

Quigley, J.D., R.E. Strohbehn, C.J. Kost, and M.M. O’Brian.  2001.  Formulation of colostrum supplements, colostrum replacer and acquisition of passive immunity in neonatal calves.  J. Dairy Sci. 84:2059-2065.

Quigley, J.D. III, A.F. Carson, and J. Polo. 2002. Immunoglobulin derived from bovine plasma as a replacement for colostrum in newborn lambs. Vet. Therap. 3(3):262-269.

 
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Weaning

Coffey, R. D., and G. L. Cromwell. 2001. Spray-dried animal plasma in diets for weanling pigs. Pig News Info. 22:39N-48N.

Crenshaw, J.D., J. Polo, and J. Campbell. 2013. SDP effective in swine diets for various stages. Feedstuffs, Vol 85 (25):12-13.

Jiang, R., X. Chang, B. Stoll, K. J. Ellis, R. J. Shypailo, E. Weaver, J. Campbell, and D. G. Burrin. 2000.  Dietary plasma protein is used more efficiently than extruded soy protein for lean tissue growth in early-weaned pigs. J. Nutr. 130:2016-2019.

Kats, L. J., J. L. Nelssen,  M. D. Tokach,  R. D. Goodband,  J. A. Hansen and J.L., Laurin. 1994. The effect of spray-dried porcine plasma on growth performance in the early-weaned pig. J. Anim. Sci. 72:2075–2081.

Torrallardona, D. 2010. Spray dried animal plasma as an alternative to antibiotics in weanling pigs – A review. Asian-Aust. J. Anim. Sci. 23(1):131-148

Van Dijk, A. J., H. Everts, M.J.A. Nabuurs, R.J.C.F. Margry, and A.C. Beynen. 2001. Growth performance of weanling pigs fed spray-dried animal plasma: a review. Livestock Production Sci. 68:263–274.

Van Dijk, A.J., et al.  2001. Small intestinal morphology in weaned piglets fed a diet containing spray-dried porcine plasma. Research in Veterinary Science 71:17-22.

 
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